Diabetes type 1 is a result of the human body’s own immune system destroying its pancreatic islet beta cells, as a result daily insulin injections are needed to manage the person’s blood glucose levels. A treatment makes use of cord blood stem cells to re educate a diabetic’s own T cells and thus reactivate pancreatic function decreasing the need to have insulin.
Cord blood stem cells are stem cells derived from cord blood, the blood that remains in a newborn’s umbilical cord following birth.
New Therapy Uses Cord Blood Stem Cells To Reverse Diabetes
Stem Cell Educator therapy gradually passes lymphocytes removed from the person’s blood across immobilized cord blood stem cells from healthy donors. After 2 to 3 hours inside the device the re-educated lymphocytes will be returned to the patient. The patients’ improvement was checked at 4, 12, 24 and 40 weeks following therapy.
C-peptide is a protein fragment created as a byproduct of insulin production and are used to figure out how effectively beta cells are working. After 12 weeks following treatment all of the individuals who had been given the therapy experienced improved C -peptide levels. The levels carried on improving at 24 weeks and was maintained up until to the finish of the research. This meant that the daily insulin dosage needed to manage their blood glucose levels can be reduced. According to these outcomes the glycated hemoglobin (HbA1C) indicator of longterm glucose control also decreased for patients getting the cord blood stem cells therapy, however, not the control group.
The study also found an improved autoimmune control in these people. Stem Cell Educator therapy elevated the proportion of regulatory T lymphocytes within the blood of individuals from the treatment group. Additional immune function markers, like TGF-beta1 improved as well. The outcomes indicate that it’s this progress in autoimmune management, mediated through the autoimmune regulator AIRE in the cord blood stem cells, that enables the pancreatic islet beta cells to heal.
Reference for: New Therapy Uses Cord Blood Stem Cells To Reverse Diabetes
