The development will help research into the condition as it will enable scientists to model the disease in the laboratory to shed light on why certain nerve cells die.
Scientists took skin samples from a patient diagnosed with one of the most progressive types of Parkinson’s disease.
The research then used these skin cells to generate brain nerve cells affected by Parkinson’s disease.
The ability to generate these nerve cells will make it easier to monitor the effectiveness of potential new drugs that could slow or halt progress of the condition.
The aim would be to find drugs that can prevent the death of these key cells – known as neurons – which break down as a result of Parkinson’s disease.
Dr Tilo Kunath said: “Current drugs for Parkinson’s disease alleviate symptoms of the condition. Modelling the disease in a dish with real Parkinson’s disease neurons enables us to test drugs that may halt or reverse the condition.
“This study provides an ideal platform to gain fresh insight into the condition, and opens a new area of research to discover disease-modifying drugs.”
The neuron cells were generated from a patient with a form of Parkinson’s disease that progresses rapidly and can be diagnosed in people in their early 30s.
People with this form of Parkinson’s disease have twice as many of the genes that produce a protein – alpha synuclein – compared with the general population.
Although this form of Parkinson’s disease is rare the protein involved is linked to virtually all types of the disease.
Dr Michael Devine said, “Understanding such a progressive form of the disease will give us insight into different types of Parkinson’s disease. As this type of Parkinson’s disease progresses rapidly it will also make it easier to pick up the effects of drugs tested to prevent nerve cells targeted by the disease from dying.”
Dr Kieran Breen said: “Although the genetic mutation that leads to this progressive form of Parkinson’s disease is rare this exciting study has the potential to bring about a huge breakthrough in Parkinson’s disease research.
“This is just the kind of innovative research that Parkinson’s UK is committed to funding as we move closer to a cure.”
References:
1. University of Edinburgh
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